How missing "sugar trees" cause a rare disorder... Click here to learn how aberrant glycosylation causes a rare disorder.
Learn about the underlying biology of PMM2-CDG, what treatment options are available, and how you can make a difference to fill a very urgent gap. This video was produced by Alpha Epsilon Omega with support from the Amour Fund.
Danio rerio, commonly referred to as the zebrafish, is an aquatic vertebrate that can be used to examine human glycosylation disorders. Zebrafish are especially powerful in studying developmental disorders and screening for therapeutics as their proteins and genes are similar to that of humans. The FoG and associated researchers are currently working on developing a zebrafish disease model of ALG9-CDG and ALG12-CDG by utilizing Crisper/Cas9 genome editing technology.
The following video demonstrates how zebrafish are used to study developmental and neuromotor diseases.
Mail: Foundation Glycosylation Saint John Regional Hospital Foundation Level One, Saint John Regional Hospital 400 University Avenue P.O. Box 2100 Saint John, New Brunswick, Canada E2L 4L2