6th Annual Millidgeville FoG Cup
The FoG Cup was established in 2012 as an opportunity for old friends to get together and play ball hockey for a good cause. Funds raised help to advance the research of Congenital Disorders of Glycosylation (CDG). Money collected is used to assist with ongoing projects and research. Thank you to Terence Sullivan, our devoted annual organizer, and to friends and supporters who have assisted with or participated in the FoG Cup.
2017 FoG Cup
2017 will mark our 6th annual running of the Millidgeville FoG Cup Challenge and the 4th annual Kid's FoG Cup. The 2017 Millidgeville FoG Cup will be held on June 10th at Millidegville North School in Saint John, New Brunswick. Kid's Cup registration will run between 8:30am and 9am. Teams will be equally balanced by throwing of sticks and the games will begin at 9:15am. The Kid's Cup Championship Game is scheduled for noon.
Registration for this year’s adult tournament will begin at 1pm with The Throwing of Sticks for team selection and games to begin at 2pm.
A recommended donation of $25 per player, both youth and adult, will be collected prior to playing. If paying by cheque please make it payable to Foundation Glycosylation. Charitable receipts will be sent out by mail to all participants from the Saint John Regional Hospital Foundation.
Many Thanks to Dr. Lester Perez!
Lester began work for the FoG as a full time laboratory research technician in November 2015. Working in the Pulinilkunnil Laboratory, a great deal has been accomplished during his time with the FoG. A greater understanding of the relevance of glycosylation in proteostatic and mitochondrial signaling pathways has been gained through the study of fibroblasts using transcriptomic, proteomic and high-resolution respirometry analysis. In cells with defective glycosylation, impaired protein synthesis and growth have been identified and analysed. Studies have shown a loss of anabolic signaling and down regulation of lysosomal autophagy with lysosomal dysfunction. Studies have also revealed remodelling of the mitochondrial respiration profile with concomitant disruption of the endoplasmic reticulum and lysosomal function. The data characterizes abnormalities involving endoplasmic reticulum, mitochondrial and lysosomal function at the molecular level that help to explain clinical complications associated with CDG and underscore the importance of N-linked glycosylation in health and disease.
We thank Lester for his commitment and work in glycosylation research and we congratulate Lester on his new position as Research Technician T8 with Dalhousie Medicine New Brunswick!
Dr. Webster and Dr. Perez in the zebrafish laboratory at Dalhousie Medicine New Brunswick